Etizolam Powder 99% Pure

Etizolam Powder 99% Pure

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Etizolam Powder 99% Pure

Etizolam Powder 99% Pure: Etizolam is a designer chemical or research chemical. Etizolam powder is mainly used for the short-term treatment of anxiety and panic attacks. It is also used for short term treatment of insomnia. Etizolam is a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring, making the drug a thienodiazepine.

CAS: 40054-69-1
Formula: C17H15ClN4S
Molecular weight: 342.07
Compound purity: 99.7%
Appearance: Powder

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Etizolam Powder 99% Pure

Etizolam Powder 99% Pure: Etizolam (marketed under many brand names) is  a thienodiazepine derivative which is a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring and triazole ring has been fused, making the drug a thienotriazolodiazepine.

Brand names

Etilaam, Sedekopan, Etizest, Etizex, Pasaden or Depas

Although a thienodiazepine, etizolam is clinically regarded as a benzodiazepine because of its mode of action via the benzodiazepine receptor and directly targeting GABAA receptors. It possesses anxiolytic, amnesic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Etizolam is an anxiolytic found to have lower tolerance and dependence liability than benzodiazepines. It was patented in 1972 and approved for medical use in 1983. As of April 2021, the export of Etizolam has been banned in India

Medical uses

  • Short-term treatment of insomnia.
  • Anxiety disorders such as OCD and general anxiety disorder, however mostly considered a short-term medication to then be used purely on an at need basis

Side effects

Long term use may result in blepharospasms, especially in women. Doses of 4 mg or more may cause anterograde amnesia.  In rare cases, erythema annulare centrifugum skin lesions have resulted.

Tolerance, dependence and withdrawal

Abrupt or rapid discontinuation from etizolam, as with benzodiazepines, may result in the appearance of the benzodiazepine withdrawal syndrome, including rebound insomnia. Neuroleptic malignant syndrome, a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt withdrawal from etizolam. This is particularly relevant given etizolam’s short half life relative to benzodiazepines such as diazepam resulting in a more rapid drug level decrease in blood plasma levels.

In a study that compared the effectiveness of etizolam, alprazolam, and bromazepam for the treatment of generalized anxiety disorder, all three drugs retained their effectiveness over 2 weeks, but etizolam became more effective from 2 weeks to 4 weeks. Administering .5 mg etizolam twice daily did not induce cognitive deficits over 3 weeks when compared to placebo.

When multiple doses of etizolam, or lorazepam, were administered to rat neurons, lorazepam caused downregulation of alpha-1 benzodiazepine binding sites (tolerance/dependence), while etizolam caused an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects). Tolerance to the anticonvulsant effects of lorazepam was observed, but no significant tolerance to the anticonvulsant effects of etizolam was observed. Etizolam therefore has a reduced liability to induce tolerance, and dependence, compared with classic benzodiazepines.

Etizolam may represent a possible anxiolytic of choice with reduced liability to produce tolerance and dependence after long-term treatment of anxiety and stress syndromes


Cases of intentional suicide by overdose using etizolam in combination with GABA agonists have been reported. Although etizolam has a lower LD50 than certain benzodiazepines, the LD50 is still far beyond the prescribed or recommended dose. Flumazenil, a GABA antagonist agent used to reverse benzodiazepine overdoses, inhibits the effect of etizolam as well as classical benzodiazepines such as diazepam and chlordiazepoxide.

Etizolam overdose deaths are rising – for instance, the National Records of Scotland report on drug-related deaths, ‘street’ Etizolam was a factor in (“implicated in, or potentially contributed to”) 752, or 59%, of drug-related deaths in Scotland in 2019. It is important to highlight that more than one drug contributed to the vast majority of the deaths (by way of comparison, opiates and opioids were a factor in 1092, or 86%, of drug-related deaths)

Additional Information


100g, 10g, 500 mg, 50g


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