MDAI Crystal Powder

MDAI Crystal Powder

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MDAI (5,6-methylenedioxy-2-aminoindane) is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent (SSRA) in vitro and produces entactogen effects in humans.

The chemical structure of MDAI is indirectly derived from that of the illicit drug MDA, but the alpha-methyl group of the alkyl amino amphetamine side chain has been bound back to the benzene nucleus to form an indane ring system, which changes its pharmacological properties substantially.

MDAI can be produced from 3-(3,4-methylenedioxyphenyl)propionic acid which is converted to the acid chloride and then heated to produce 5,6-Methylenedioxy-1-indanone. Treatment of the indanone with amyl nitrite in methanol with HCl afforded the hydroxyimino ketone. This is reduced to the 2-aminoindan following a modification of Nichols’ earlier method from a paper discussing DOM analogues,using a Pd/C catalyst in glacial acetic acid with catalytic H2SO4 . The chemical structure of MDAI is indirectly derived from that of the illicit drug MDA, but the alpha-methyl group of the alkyl amino amphetamine side chain has been bound back to the benzene nucleus to form an indane ring system, which changes its pharmacological properties substantially.

Effects

MDAI in powder form

The family of drugs typified by MDMA produce their effects through multiple mechanisms of action in the body, and consequently produce three distinct cues which animals can be trained to respond to: a stimulant cue typified by drugs such as methamphetamine, a psychedelic cue typified by drugs such as LSD and DOM, and an “entactogen-like” cue which is produced by drugs such as MDAI and MBDB. These drugs cause drug-appropriate responses in animals trained to recognize the effects of MDMA, but do not produce responses in animals trained selectively to respond to stimulants or hallucinogens. Because these compounds selectively release serotonin in the brain but have little effect on dopamine or noradrenaline levels, they can produce empathogenic effects but without any stimulant action, instead being somewhat sedating.

Very high doses can be fatal in rats with a 50% fatality rate for those subcutaneously injected with 28 mg/kg of MDAI. This is a result of the way serotonin release interferes with thermoregulation

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MDAI Crystal Powder

What is MDAI?

MDAI Crystal Powder: 5,6-Methylenedioxy-2-aminoindane is a research chemical that was first chemically profiled and synthesized at Purdue University by David E. Nichols. Due to its interesting property as a non-neurotoxic selective serotonin releasing agent (SSRA), it has been a very popular research chemical in the USA, UK, and Europe. Although only licensed for in vitro (outside living organism) research it is known from other studies that it is not only non-neurotoxic but would act as an entactogen should it ever be licensed for in vivo research. it became unavailable for a short period within the UK, but is now back, with even higher purity.

What is MDAI used for?

Due to the chemical structure and relatedness to other SSRI’s, it is reasonable to assume that MDAI would bind to either the serotonin receptor or the serotonin transporter protein. Researchers could use a synthetic membrane infused with these two proteins to determine which one it binds to. The affinity could be determined, or a competitive ligand binding assay could be performed to determine if there is any preference for a particular protein.

Chemistry students may wish to use it as a primary reagent, or it could be used as a reference sample for chemical libraries of NMR, HPLC, FTIR, and GC/MS analysis. These results or even the sample itself could be used by toxicologists and forensic scientists.

Dosage

There is no recommended dose since for these drugs because it isn’t for human consumption. In this way, it is sold uniquely as a research chemical for research purposes.

Side effects of MDAI

The clinical effects of most new designer drugs can be described as either hallucinogenic, stimulant, or opioid-like. They may also have a combination of these effects due to designer side-chain substitutions.

Like other designer drugs, the use of this chemical can cause strong side effects; the substance is not clinically tested nor licensed in any way as a product for consumption! Therefore this drug is NOT FOR HUMAN CONSUMPTION but for SCIENTIFIC RESEARCH ONLY!

Chemical Consulting Network is extremely proud to be one of few vendors of the new batch of MDAI, with stock amounts available up to 10g. We have managed to acquire a fresh batch of laboratory-grade 99% + pure MDAI. You will receive a tracking number the same day as delivery and you will receive a recorded service as standard for our customers.

All orders of MDAI Crystal are strictly not for human consumption and must only be used for legitimate research chemical purposes by customers over the age of 18.

Additional Information

Quantity

100g, 10g, 500g, 50g

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