Roxicodone (Oxycodone Hydrochloride) | 30mg

Roxicodone (Oxycodone Hydrochloride) | 30mg

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DESCRIPTION

ROXICODONE® (oxycodone hydrochloride tablets USP) is an opioid analgesic.

Each tablet for oral administration contains 5 mg, 15 mg or 30 mg of oxycodone hydrochloride USP.

Oxycodone hydrochloride is a white, odorless crystalline powder derived from the opium alkaloid, thebaine. Oxycodone hydrochloride dissolves in water (1 g in 6 to 7 mL) and is considered slightly soluble in alcohol (octanol water partition coefficient is 0.7).

Chemically, oxycodone hydrochloride is 4, 5α-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6- one hydrochloride and has the following structural formula:

 

 

ROXICODONE<sup>®</sup>® (Oxycodone Hydrochloride) Structural Formula Illustration

C18H21NO4•HCl
MW 351.82

The 5 mg ROXICODONE® tablet contains inactive ingredients: microcrystalline cellulose and stearic acid. The 15 mg and 30 mg tablets contain the following inactive ingredients: microcrystalline cellulose; sodium starch glycolate; corn starch; lactose; stearic acid; D&C Yellow No. 10 (15 mg tablet); and FD&C Blue No. 2 (15 mg and 30 mg tablets).

The 5 mg, 15 mg and 30 mg tablets contain the equivalent of 4.5 mg, 13.5 mg and 27.0 mg, respectively, of oxycodone free base.

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Roxicodone (Oxycodone Hydrochloride) | 30mg

DESCRIPTION: ROXICODONE
ROXICODONE® (oxycodone hydrochloride tablets USP) is an opioid analgesic.
Each tablet for oral administration contains 15 mg or 30 mg of oxycodone hydrochloride
USP.
Oxycodone hydrochloride is a white, odorless crystalline powder derived from the opium
alkaloid, thebaine. Oxycodone hydrochloride dissolves in water (1 g in 6 to 7 mL) and is
considered slightly soluble in alcohol (octanol water partition coefficient is 0.7).
Chemically, oxycodone hydrochloride is 4, 5α-epoxy-14-hydroxy-3-methoxy-17­
methylmorphinan-6-one hydrochloride and has the following structural formula:
The tablets contain the following inactive ingredients: microcrystalline cellulose; sodium
starch glycolate; corn starch; lactose; stearic acid; D&C Yellow No. 10 (15 mg tablet);
and FD&C Blue No. 2 (15 mg and 30 mg tablets).
The 15 mg and 30 mg tablets contain the equivalent of 13.5 mg and 27.0 mg, respectively,
of oxycodone free base.
CLINICAL PHARMACOLOGY
Pharmacology:
The analgesic ingredient, oxycodone, is a semi-synthetic narcotic with multiple actions
qualitatively similar to those of morphine; the most prominent of these involves the
central nervous system and organs composed of smooth muscle.
Oxycodone, as the hydrochloride salt, is a pure agonist opioid whose principal therapeutic
action is analgesia and has been in clinical use since 1917. Like all pure opioid agonists, there is no ceiling effect to analgesia, such as is seen with partial agonists or non-opioid
analgesics. Based upon a single-dose, relative-potency study conducted in humans with
cancer pain, 10 to 15 mg of oxycodone given intramuscularly produced an analgesic effect
similar to 10 mg of morphine given intramuscularly. Both drugs have a 3 to 4 hour
duration of action. Oxycodone retains approximately one half of its analgesic activity
when administered orally

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Pack of 5, Single

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